Charlie Murphy finally succumb to Leukemia. The popular comedian lost his wife to cancer just 8 years ago.

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Charlie was Eddie Murphy’s brother, but he was also famous in his own right. He gained international superstardom while on The Dave Chapelle Show.

Charlie Murphy, Eddie’s older brother, and a very successful and popular stand-up comedian in his own right has died … TMZ has learned.

According to Charlie’s manager, he died from leukemia Wednesday morning in a NYC hospital. He’d been going undergoing chemotherapy. Family members tell us they’re absolutely shocked because they thought he was getting better.

We’re told the family would call him frequently, and he’d even joke they were calling too much.

Charlie famously co-starred on “Chappelle’s Show” in some of Dave’s most memorable skits … including the nights Charlie partied with Rick James and Prince.